Although HPV infection is a major cause of cervical cancer, adolescents in developing nations still have low levels of awareness and vaccination coverage. The current descriptive study evaluated the attitudes and knowledge of adolescent girls in Uttar Pradesh about HPV infection and vaccination. There were 240 participants in all, 52 of whom received vaccinations. Descriptive and inferential statistics, such as Pearson's correlation, were used to analyze the data. The results showed that 58.3% had a positive attitude and 52.5% had good knowledge. Increased awareness greatly increases vaccine acceptance, as evidenced by the strong positive correlation (r = 0.89, p < 0.001) that was found.