Department of Pharmacology, Era’s Lucknow Medical College and Hospital, Era University, Sarfarazganj, Lucknow, UP, India.

Consultant, Obs and Gynae, Apollomedics Superspeciality Hospital, Lucknow, UP, India.

Adverse drug reactions are a major contributor to morbidity and mortality. Though augmented reactions are common, but bizarre ones are not infrequent. Drug-induced anaphylaxis can occur with any medication, but with pantoprazole, it is not frequently reported. Two cases of anaphylaxis with pantoprazole will be discussed in this case report. Doctors need to recognize the side effects of pantoprazole that may trigger anaphylaxis, an allergic condition. They should exercise caution and avoid prescribing it without first determining the patient's allergic status and taking a complete medical history.