Association between Glycemic Control and Lipid Profile among Newly Diagnosed Type 2 Diabetes Mellitus Patients
Author:
Mohd Misbahuzzama Khan
Department of General Medicine, Maharaja Suheldev Autonomous State Medical
College, Bahraich, Uttar Pradesh, India.
Upendra Kumar Verma
Department of General Medicine, Maharaja Suheldev Autonomous State Medical
College, Bahraich, Uttar Pradesh, India.
Rajat Mishra
Department of General Medicine, Maharaja Suheldev Autonomous State Medical
College, Bahraich, Uttar Pradesh, India.
Abstract:
Background: The association between
Type 2 diabetes mellitus (T2DM) and dyslipidemia has a long history of developing,
but the latter has become one of the key factors of the development of
cardiovascular-related illness. Therefore, early detection of lipid
abnormalities in patients who were just diagnosed with the T2DM is crucial to
the effective minimization of health risks.
Objective: This research aimed to determine
the frequency and specific features of dyslipidemia in a cohort of
newly-identified T2DM patients.
Methods: Cross-sectional and
observational study was carried out on newly diagnosed the T2DM subjects aged
30 to 65 years in a specialized medical facility. The respondents were tested
in terms of fasting blood sugar (FBS), post-meal glucose (PPBS), HbA1c and the
complete lipid profile. The 2018 AHA Guidelines were used to define
dyslipidemia. The data processing involved use of t-tests and correlation
coefficients of Pearson.
Results:
Higher
prevalence of dyslipidemia was observed with study group, with mean
triglyceride concentrations being significantly higher in diabetic men (217.7
mg/dL) than with diabetic women (187.3 mg/dL). The group identified as
dyslipidemic was characterized by notably increased mean levels of HbA1c (7.86
± 2.1), FBS (153.0 ± 33.4 mg/dL), and PPBS (261.4 ± 60.4). It was found that
HbA1c was strongly positively correlated with FBS (p < 0.001), whereas
moderate value of correlation was observed between FBS and total cholesterol,
LDL cholesterol and between PPBS and triglycerides (r = 0.664).
Conclusion: The incidence of dyslipidemia is
extremely high even at the first stage of the diagnosis of Type 2 diabetes and
it is closely linked with hypertrophic control over blood sugar levels. It is
strongly recommended that regular lipid screening should be part and parcel of
the initial clinical examination on all patients with diabetes with the view of
reducing the risk of developing heart related complications in the future.
Keywords:
Hyperglycemia , Increased HbA1C ,Increased LDL , Triglycerides, VLDL