Volume-12 Number-3, 2025 / Review Article

A Comprehensive Approach to Hyperlipidemia Management for Cardiovascular Disease and Therapeutic Interventions: Integrating Lifestyle Modifications, Ayurveda, and Pharmaceutical Treatments

Author:
Muneshwar Rajput
Central Research Laboratory, Department of Biotechnology,  Era’s Lucknow Medical College & Hospital, Era University, Lucknow, Uttar Pradesh, India- 226003.
Saliha Rizvi
Central Research Laboratory, Department of Biotechnology,  Era’s Lucknow Medical College & Hospital, Era University, Lucknow, Uttar Pradesh, India- 226003.
Pushpendra D. Pratap
Central Research Laboratory, Department of Biotechnology,  Era’s Lucknow Medical College & Hospital, Era University, Lucknow, Uttar Pradesh, India- 226003.
Syed Tasleem Raza
Central Research Laboratory, Department of Biotechnology,  Era’s Lucknow Medical College & Hospital, Era University, Lucknow, Uttar Pradesh, India- 226003.
Zeba Siddiqi
Department of Medicine, Era’s Lucknow Medical College & Hospital, Era University, Lucknow, Uttar Pradesh, India- 226003.
Vineeta Khare
Department of Microbiology, Era’s Lucknow Medical College & Hospital, Era University, Lucknow, Uttar Pradesh, India- 226003.
Abstract:
Hyperlipidemia refers to a metabolic disorder where plasma lipid levels are abnormal. It is marked by increased amounts of triglycerides, cholesterol, and lipoproteins (VLDL, LDL), and reduced HDL levels, which together, contribute to the development of cardiovascular diseases (CVD) and increase the risk thereof. It is classified into hypertriglyceridemia, hypercholesterolemia, mixed hyperlipidemia, and familial forms, depending on the predominant lipid abnormality. The condition arises due to genetic predisposition, dietary habits, sedentary lifestyle, obesity, diabetes, and certain medications. Often asymptomatic, severe cases may present with xanthomas or xanthelasmas. Diagnosis depends on lipid profile tests. Preventive measures mainly include change in diet, regular physical activity, keeping a healthy weight, and general lifestyle modifications. Therapeutic interventions consist of drug utilization such as statins, fibrates, niacin, ezetimibe, bile acid sequestrants, and omega, 3 fatty acids, PCSK9 inhibitors, lomitapide, and mipomersen. Comprehensive management through lifestyle and therapeutic approaches is crucial in reducing CVD risk and associated complications.
Keywords:
Ayurveda, Cardiovascular Disease, Herbal Remedies, Lipid-lowering Therapy, Lifestyle Modifications, Pharmaceutical Treatments.

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Download PDF View in DOI 10.24041/ejmr.2025.51