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Volume-12 Number-3, 2025 / Review Article

Exploring Withania Somnifera: A Novel Immunomodulatory and Anticancer Pharmaceutical Agent

Author:

Mohammad Akram

Department of Biochemistry of Paramedical Sciences, Satish Chandra Pandey Memorial College of Nursing and Paramedical Sciences, Gonda-271003, UP, India

Farheen Ameer Khan

Department of Pharmacy, Hygia Institute of Pharmaceutical Education and Research, Faizullahganj, Lucknow-226020, UP, India.

Vivek Ranjan Patel

Department of Biochemistry, Era’s Lucknow Medical College & Hospital, Era University, Lucknow, Uttar Pradesh, India- 226003.

Shubham Saini

Department of Biochemistry of Paramedical Sciences, Satish Chandra Pandey Memorial College of Nursing and Paramedical Sciences, Gonda-271003, UP, India

Abstract:

Background: Traditional chemotherapy for cancer has a number of major problems, such as recurrence, drug resistance, high costs, late discovery, systemic toxicity, and limited specificity. These problems make life worse and make treatment less effective. So, switching to new phytotherapy is a cost-effective and side-effect-free way that can work well with traditional treatments.

Aim: This review examines the unique immunomodulatory and anticancer characteristics of W. somnifera, emphasizing its effectiveness and potential in the treatment of cancer through direct cytotoxic effects on cancer cells and immune pathway modulation. W. somnifera may help slow the growth of several cancers, including those that affect the liver, cervix, breast, brain, colon, skin, lungs, and prostate, according to preliminary lab-based research. These findings suggest that it could be a promising natural option alongside standard cancer treatments. However, W. somnifera’s stability, bioavailability, and target, selectivity limit its clinical use.

Method: Method of data extraction in a review article on W. somnifera involves systematically gathering and analyzing relevant information from primary research studies to address specific research questions or objectives.

Conclusion: Nanotechnology based W. somnifera’s administration has improved its solubility, stability, absorption, and cancer cell delivery to improve cancer treatment outcomes. Further research uncovering the mechanism of W. somnifera and its integration into traditional cancer therapies could provide complete approach to treatment.

Keywords:

Anticancer, Cancer, Immunomodulation, Pharmaceutical Agent, Phytotherapy, Withania somnifera.

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View in DOI 10.24041/ejmr.2025.45