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Volume-12 Number-3, 2025 / Original Article

Successful Repigmentation of Recalcitrant Stable Vitiligo with Autologous Non-cultured Epidermal Cell Suspension Technique

Author:
Savita Chaudhary
Department of Dermatology, Era’s Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh, India-226003
Gopal Prasad Poddar
Department of Dermatology, Era’s Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh, India-226003
Moin Ahmad Siddiqui
Department of Dermatology, Era’s Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh, India-226003
Ratnika, Ketki
Department of Dermatology, Era’s Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh, India-226003
Reyan Abdul Jamil
Department of Dermatology, Era’s Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh, India-226003
Abstract:
Introduction: Vitiligo is a chronic condition characterized by loss of skin pigment, often unresponsive to medical treatment when the disease remains inactive. The Autologous non-cultured epidermal cell suspension (NCES) technique has proven to be an effective surgical option for such refractory cases.
Methods: In this study, 10 patient with a single, stable vitiligo patch, showing no response to conventional treatment, underwent NCES. Epidermal cells were isolated from a thin skin graft taken from pigmented skin. After processing the cells with trypsin and centrifugation, the cell suspension was applied to the prepared recipient area. Postoperative care included topical treatments and phototherapy. Clinical assessment and photographic documentation were performed during follow-up visits
Results: The patient presented with gradal repigmentation, with significant improvement by 8 weeks and excellent repigmentation (> 75%) by 12 weeks. The procedure was well tolerated, with only mild, transient adverse effects such as burning sensation and post-inflammatory hyperpigmentation.
Conclusion: NCES is a safe, effective, and cosmetically satisfactory surgical intervention for non-progressive vitiligo resistant to medical treatment.
Keywords:
Vitiligo, Non-cultured epidermal cell suspension, Surgical treatment, Repigmentation

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Copyright (c) 2026 Era's Journal of Medical Research

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Download PDF View in DOI 10.24041/ejmr.2025.35