Liquisolid Compact Techniques – A Latest Review

Author:

Neelam Yadav

Abstract:

Introduction: A very large proportion of drugs that are being developed exhibits low water solubility, particularly those drugs which are presented under the (BCS) Class II. This low solubility frequently leads to the poor bioavailability, that leads to difficulties in drug formulation. This review article explores the liquisolid compacts strategy that significantly helps to overcome this problem and aims to enhance rate of drug dissolution and bioavailability of drug in the systemic circulation. Methods: The liquisolid formulation involves the dissolving or introducing pure drug into a non-volatile liquid base, after that blending it with compatible polymer-based carrier material and coating material to compose compressible powder with no moisture. By increasing the available surface, boosting wettability and encouraging localized dissolution at the powder-solvent interface. Results: So, this approach is adjustable for sustained-release formulations. The liquisolid formulation offers a simple and efficient method to boost both the dissolution and absorption of drugs with low water solubility.by turning them into a free-flowing moisture free powders that can be directly compressed into a tablet. Conclusion: this method enhances the drug bioavailability in the systemic circulation and it is much more affordable than other methods and easy to apply using standard manufacturing methods.

Keywords:

Bioavailability, BCS Class II Drugs, Dissolution Rate, Liquisolid Systems, Solubility Enhancement.