A NEW MULTI SPECIALITY JOURNAL

Welcome to Era's Journal of Medical Research Center

From the Editor's Desk

Era's Journal of Medical Research

miRNA AND CANCER METASTASIS

      The simple perception that cancer killed a patient because it had spread, is not simple, rather is too complicated to be fully understood till date. This was revealed rst by the investigators who were trying to investigate this process in detail. The idea that tumor cells got deposited in the nearby areas by direct access and to distant organs via blood stream was again found to be a simplistic conclusion. A deeper insight on the process exposed the shallowness of our thinking because body's tissue and cell network were too dense to allow any cell to just get-in, in its midst and/or allow a simple walking or strolling of a malignant rogue amongst it's domain.
The next level of metastasis riddle was as to why in most tumors, the cells metastasize to certain specic organ-sites. But why at specic sites only a cancer deposits its cells. In 1889, Stephan Paget's had proposed a hypothesis (seed and soil theory) revolving around soil (specic organ) and seed (cancer cell) theory. Today this has been given a different perspective: “it is due to micro-environment” of that organ or tissue where the cancer cells deposits and thrive. However which factors precisely govern this mechanism, needs further investigations.
As if this all was not enough trouble to bother the scientic investigators, some bright mind showed that this activity and process is not only at local level but, there is a high command (very much like in political parties), which nally sends its dictat transmitted through its messengers, that is genetic material here in the form of DNAs, RNAs and miRNA which controls signals.
Moreover, these malignant cells, like terrorist in our society, not only followed pre-determined sets of rules in shape of modules; but also moved singly and independently like lone wolf; hid amidst normal people (cells and tissues here), dare to survive in adversaries, kept increasing its capacity and capability, then strike at best amplitude when nobody was suspecting.
This migration of single and independent tumor malignant cell takes place in the very early course of the malignant tumor's life cycle.
Now, where do we stand today with all this early speculations and insights gained We now know for sure that we could not treat or completely eradicate some malignant tumors because sometimes our troops of medicines could not kill all the tumor cells, rather some cells quietly escape, in the very early stage of a malignant tumors development, hid and wait for circumstances to become right to re-emerge.
Thus the tumor metastasis has come to be understood as a very complex process, controlled by genetic domain in the body through micro-RNAs which either up-regulate or down-regulate the suppresser or proto-onco gene.
There are genes and local micro-environmental factors which help via “Epithelial myo- epithelial transmission”, (EMT) and/or its reverse process, “myo-epithelial transmission (MET).
These tumor cells have surface receptors as markers which help in these on-going processes.
There are substances, molecules and signals which loosen the tight web network between cells to allow these malignant cells to move. There are still other substances which disrupt the intact basement membranes which act like a wall preventing cells to move away.
Paradoxically at times our own chemotherapeutic management helps create favorable environment for tumor cells to grow after developing resistance.
Therefore to understand tumor metastatic process more and more investigations are needed through biochemical and molecular biology studies, associated with genetic processes including micro- RNA based control and epigenetic inuences governing metabolic pathways regulated by miRNAs.


Prof. A.N. Srivastava
Director Research
Era's Lucknow Medical College & Hospital, Lucknow
Email: anscsmmu@gmail.com


Prof. A.N. Srivastava (Editor in Chief ) View in PDF

INDEXING Crossref DOI prefix : 10.24041

  • ebsco
    EBSCO
  • index copernicus
    INDEX COPERNICUS
  • crossref
    CROSSREF
  • DRJI
    DRJI
  • I2OR
    I2OR
  • innospace
    INNOSPACE
  • rootindexing
    ROOTINDEXING
  • Avicenna Scientific
    AVICENNA SCIENTIFIC
  • PIF
    PIF

TABLE OF CONTENTS

Era's Journal of Medical Research: Volume-3 Number-2

Original Articles
1.

DERANGEMENT IN AUTONOMIC FUNCTIONS WITH ELEVATED BLOOD PRESSURE
Arsalan Moinuddin
Department of Physiology,

Himalayan Institute of Medical Sciences, SRHU, Jollygrant, Dehradun, India.

View in PDF
2.

PREVALENCE OF TINEA CAPITIS IN A TERTIARY CARE HOSPITAL,NORTH INDIA
Priyanka Shukla,
Fareya Haider,
Shadma Yaqoob,
Vineeta Khare,
Mastan Singh

Department of Microbiology
Era's Lucknow Medical College & Hospital, Lucknow.

View in PDF
Review Articles
1.

YOGIC MODULES OF CLINICAL MANAGEMENT OF DEPRESSION
Rajesh Kumar Raj
Department of Psychology
Wonkwang Digital University, South Korea.

View in PDF
2.

ANAPLASTIC LYMPHOMA KINASE (ALK) GENE REARRANGEMENT DETECTION USING FLUORESCENE IN-SITU HYBRIDIZATION (FISH) IN LUNG CANCER PROGNOSTICATION
Alok Singh,
A.N. Srivastava,
Pooja Singh

Department of Pathology
Era's Lucknow Medical College and Hospital, Lucknow, India.-226003

View in PDF
3.

PSYCHOLINGUISTICS: A VIEW
Hasibuddin
Department of Humanities
Kashi Institute of Technology, Varanasi.

View in PDF
Case Reports
1.

SYNCHRONOUS CLEAR CELL RENAL CELL CARCINOMA AND TUBULOCYSTIC RENAL CELL CARCINOMA
Manoj Jain,
Shruti Agrawal,
Sushila Jaiswal,
Anil Mandhani
Department of Pathology and Department of Urology & Kidney Transplantation
Sanjay Gandhi Postgraduate Institute of Medical Sciences , Lucknow- 226014

View in PDF
2.

RARE CASE OF CERVICAL PROLAPSE IN PREGNANCY
Kumkum Srivastava,
Dr. Chhaya Kushwaha
Department of Obst. & Gynaecology
Era's Lucknow Medical College & Hospital, Lucknow- 226003

View in PDF
3.

TUBERCULOSIS OF THE AZYGOUS LOBE OF LUNG: CASE REPORT AND REVIEW OF LITERATURE
Saurabh Karmakar,
Ahbab Hussain,
Sakshi Batra,
Kashif Raza
Rajendra Prasad

Department of Pulmonary Medicine
Era's Lucknow Medical College & Hospital, Lucknow.

View in PDF
Short Communications
1.

PATHOLOGY OF OBESITY
Neema Tiwari
Department of Pathology
Era's Lucknow Medical College & Hospital, Lucknow.

View in PDF
Book Review :
1. TEXTBOOK OF BIOCHEMISTRY FOR MEDICAL STUDENTS
Brijesh Rathore
Department of Biochemistry,
Era's Lucknow Medical College & Hospital, Lucknow.
View in PDF